منابع مشابه
Pathology of Paget ’ s disease of bone
Paget’s disease of bone is a common metabolic disorder, which is in most cases diagnosed on the basis of its radiographic findings. Its primary bone alterations and subsequent complications constitute a complex range of pathologic pictures, which may pose diagnostic difficulties upon histologic examination. This article illustrates the spectrum of pathologic features of Paget’s disease of bone ...
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Malignant bone disease is a frequent complication of several common solid tumours including breast, lung, prostate and renal cancer. A greater understanding of tropic bone tumour cells, especially the understanding of those properties which lead to their successful growth within the bone microenvironment is the first step to devise innovative approaches. Bone metastases are generally characteri...
متن کاملPaget disease of bone in a Jurassic dinosaur
neuroimaging. I laid out the critical prediction derived from load theory, namely that visual cortex responses to distractor stimuli should depend on the level of load in the attended task, in the same manner as I had shown in my behavioural studies. About a year later, following a departmental seminar, Chris introduced me to his PhD student saying: “Geraint, this is Nilli: we will be testing t...
متن کاملThe treatment of Paget ’ s disease of bone Mini - review
The primary objective of Paget’s disease treatment is the relief of symptoms, but treatment is also commonly prescribed to prevent the development of late complications in asymptomatic subjects with active disease (i.e., above normal serum alkaline phosphatase [bALP]). An aggressive course of treatment is recommended before surgery at the site of a pagetic lesion, the aim being to reduce as muc...
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Tumor-induced osteolysis or lytic bone disease is mediated by osteoclast activation. Osteoclasts can be activated directly by products produced by tumors or indirectly through other nonmalignant cells. By reducing osteoclastic activity, bisphosphonates inhibit bone resorption. Since these agents had demonstrated efficacy in treating other diseases associated with increased bone resorption, incl...
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ژورنال
عنوان ژورنال: Nature Reviews Endocrinology
سال: 2009
ISSN: 1759-5029,1759-5037
DOI: 10.1038/nrendo.2009.188